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ORIGINAL ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 69-74

Study of the effect of Tamsulosin in the spontaneous expulsion of ureteric calculi


1 Department of Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
2 Department of Urology, Kilpauk Medical College, Chennai, Tamil Nadu, India
3 Department of Anaesthesia and Critical Care Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
4 Department of Urology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Jay Prakash
205, Roma Pearl Apartment, AECS layout, Bengaluru, Karnataka - 560 037
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ais.ais_39_18

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Background: To increase the expulsion rate and reduce the analgesic requirement, there is a great deal of enthusiasm for adjuvant pharmacological interventions which is non-invasive and cost-effective. Tamsulosin shortens hospital stay, decreases operative interference. Tamsulosin increases stone expulsion rate and decreases expulsion time and has been shown to be safe and cost effective. The aim was to study the effect of Tamsulosin in the spontaneous expulsion of calculi in the ureter and to study the side effects of use of Tamsulosin for ureteric stones. Patients and Methods: A prospective, randomized controlled study was conducted to compare the effect of Tamsulosin between two groups. This study included a total of 50 patients, 25 patients were chosen randomly and advised to take plenty of oral fluids and treated with NSAIDs (Diclofenac sodium) and the other 25 patients were treated with Tamsulosin (alpha blocker) 0.4mg HS for one month along with oral fluids and NSAIDs (Diclofenac sodium). The patients were then observed weekly and ultrasound scan was repeated after 15 days to look for any passage of calculi. If the stone was passed successfully, it was confirmed with ultrasonography. After one month if treatment failed, conservative management was discontinued and the patient was advised surgery. Independent t-test and Chi-square test' was the test of significance. Results: Majority of the patients were in the age group of 20-40 yrs. The mean size of the calculus was 7.18 mm on the right side and 6.62 mm on the left side. Out of the 25 patients who were on alpha 1 blocker (Tamsulosin) 16 patients had passed the calculi and 9 patients had no results with a success rate of 64%. In the 25 patients who were not on Tamsulosin 6 patients passed the calculi and 19 patients did not pass the calculi. Conclusion: Tamsulosin is an effective and safe drug in the management of calculi in the ureter and should be considered before ureteroscopy or extracorporeal lithotripsy for uncomplicated ureteral calculi.


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