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Year : 2015  |  Volume : 5  |  Issue : 1  |  Page : 1-6

The factors influencing carcinogenesis and its genetic and molecular basis


Department of Surgery, Late Shri Baliram Kashyap Memorial Government Medical College, Jagdalpur, Chhattisgarh, India

Correspondence Address:
S N Agrawal
Main Road, P.O. Jagdalpur - 494 001, Bastar, Chhattisgarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-9596.153138

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Cancer is a genetic disease and genetic mutation is in the heart of carcinogenesis. We attribute the defects to gene, but in fact it is their genetic protein products that regulate all cell activities, like cell division, deoxyribonucleic acid (DNA) repair, apoptosis, cell differentiation, etc. When they (gene and genetic protein) get mutated, a step ahead is taken towards carcinogenesis. The mutation leads to some basic attributes which ultimately is responsible for carcinogenesis. These are self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, unlimited replicative potential, sustained angiogenesis, invasive and metastasizing capabilities, and genomic instability due to defects in DNA repair. It is not necessary that all the attributes are essentially playing part at a given time, but some may be playing more important role than other. An endeavor is made in this article to address these attributes and their influence in carcinogenesis.


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